Libraries were quantified using the IS7 and IS8 primers59 in a quantification assay using a DyNAmo SYBR Green qPCR Kit (Thermo Fisher Scientific) on the LightCycler 480 (Roche). It involves lots of hypothesis testing and statistics which 365 Data Science also has a wonderful course on. The data generated in this study enabled us to investigate genomic transformations of and interactions between Eurasian hunter-gatherers at high resolution (Extended Data Fig. 12 Data Science YouTube Channels by Women to Follow https://doi.org/10.1038/s41586-023-05726-0, DOI: https://doi.org/10.1038/s41586-023-05726-0. Further palaeogenomic studies on Upper Palaeolithic individuals from the Balkans will be essential for understanding whether southeastern Europe represents the source of the Villabruna ancestry and a climatic refugium for human populations during the LGM. Pleistocene mitochondrial genomes suggest a single major dispersal of non-Africans and a Late Glacial Population turnover in Europe. thua808@aucklanduni.ac.nz. The genetic history of Ice Age Europe. 9) and testing the relative affinity among them using f4-statistics in the form f4(Mbuti, Epigravettian A; Epigravettian B, Epigravettian C) (Supplementary Data 2.E). Twelve-month follow-up after hospitalization for SARS-COV-2: physiology Nature 570, 182188 (2019). Okenla is also part of Atomicos Angel Programme 2021, and is an advisory board member for both Coders of Colour and the No.10 Innovation Fellowship. It can take several minutes for a query to complete, and if youre using a lot of data the whole table may be locked up. c, Admixture graph modelling of the main pre-LGM European hunter-gatherer lineages created using qpGraph. Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness . Write a sharp and effective resume in minutes and get noticed by employers. Thisancestry profile survived during the Last Glacial Maximum (25,000 to 19,000 years ago) in human populations from southwestern Europe associated with the Solutreanculture, and withthe following Magdalenian culturethat re-expanded northeastward after the Last Glacial Maximum. Synergy of Ag and AgBr in a Pressurized Flow Reactor for Selective Limits of long-term selection against Neandertal introgression. Product development is, by far, my favorite data science use case for two main reasons. Follow a proven methodology, discover how to avoid common mistakes and impress employers as the best person for the job. We love meeting interesting people and making new friends. Quat. Next, we investigated the genetic relationships between Epigravettian-associated individuals across the Italian peninsula, by reconstructing a phylogeny based on a matrix of pairwise f2 genetic distances (Fig. The analysis of biological relatedness was performed by calculating relatedness coefficient (r) based on PMR on the autosomal SNPs (Supplementary Data 1.F and Supplementary Information, section4). One of the best-known and most liked personalities in the data community, Tina is a successful YouTuber and works with one of the FAANG companies. What is Connection Map in Data Visualization? We built 1 to 8 single- and double-stranded genetic libraries for each individual and enriched them for human DNA on 1.24million single nucleotide polymorphisms6 (SNPs), which were then sequenced and yielded 0.04- to 7.64-fold coverage on average over the targeted SNPs. But she came up with a way to break down the code and create a website that she was proud of. In no time, she established herself as one of the favorite vloggers of the data community. Extended Data Fig. The pairwise f2 distance matrix of Epigravettian-associated groups was generated with qpfstats 200 in ADMIXTOOLS 7.0.2 package, with parameters allsnps: YES, scale: NO, and Mbuti.DG set as the outgroup. Bronk Ramsey, C. Bayesian analysis of radiocarbon dates. Archeol. Reads with a mapping quality below 30 were then filtered with samtools, and the consensus sequences were generated by Schmutzi69. The responsible co-authors for the material from each archaeological site are listed in Supplementary Information, section 1. Tina Huang | Continuing Studies at UVic Then we combined our newly generated genotypes with published genotypes from ancient and modern individuals from AADR v42.4 (Allen Ancient DNA Resource (https://reich.hms.harvard.edu/allen-ancient-dna-resource-aadr-downloadable-genotypes-present-day-and-ancient-dna-data) version 42.4) for downstream analysis1,4,7,14,16,23,36,37,38,39,40,42,43,45,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94. Tina Huang. Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers. Tina Huangis a data scientist currently working at a large FAANG enterprise. Rep. 11, 15005 (2021). Follow Author. Sci. Both of these books focus on the science and math behind data mining. Google Scholar. Our results show that the contact zone and the admixture patterns betweenthe Oberkassel and Sidelkino ancestries changed over time (Fig. Bioinformatics 38, 37683777 (2022). I love learning new things a. All Rights Reserved. Archaeological background, method descriptions and discussions additional to the main text, including sections 113, Figs. Admixture graphs were reconstructed using qpGraph 6450, with allsnps mode to correct for low-coverage sample and Mbuti.DG set as the outgroup. 26, 827833 (2016). F4-statistics also show that the approximately8.2ka Yuzhniy Oleniy Ostrov group from Karelia in western Russia formed by 19 genomes has comparable or lower affinity to Villabruna ancestry than all the other EHG groups (Supplementary Data 2.K). The effective population sizes (Ne) were then estimated using a maximum likelihood method, after filtering individuals with a signal of close-kin inbreeding (individuals with at least 50 cM of their genome in ROH spanning >20 cM) (Supplementary Information, section9). PubMed Central Individuals in western and southwestern Europe related to the Fournol cluster are consistently deposited in cave sites and occasionally exhibit anthropogenic marks whereas individuals related to the Vstonice cluster are buried with grave goods and/or personal ornaments and ochre in open air or cave sites in central-eastern and southern Europe, respectively (Supplementary Figs. The labels in italic denote previously published individuals without new data generated in this study. 5, 820825 (2021). 5 YouTubers That Helped Me Break Into Data Science The Roger Rabbit's Trousers (1990 film) Credits | JH Movie Collection In article number 2206752, Hao Zeng and co-workers report a soft actuator assembly capable of windassisted dispersal and lift-off/landing action under the control of a light beam.The design is inspired by the seed of dandelion, resembling several biomimetic features, i.e., high porosity, lightweight, and separated vortex ring generation under a steady wind flow. Lazaridis, I. et al. has received funding from the Van de Kamp fonds. E.A. Science 366, 708714 (2019). Int. Ancient admixture in human history. The genetic prehistory of the Baltic Sea region. Science 360, eaar7711 (2018). ADS Genomic diversity and admixture differs for stone-age Scandinavian foragers and farmers. In addition to her rich experience, including bioinformatics cancer research at OICR, Tina is a popular YouTuber with over 60K subscribers. J. Are you Tina Huang? Showcase your skills and bolster your data science credentials. Tina Huang - YouTube (eds. 2, 17561762 (2007). 255, 106796 (2021). My name is Tina and I'm a data scientist and YouTuber. Nat. Google Scholar. Feb 2015 - Jun 20161 year 5 months. Population genomics of Mesolithic Scandinavia: investigating early postglacial migration routes and high-latitude adaptation. In panel a, genetic affinity between different ancestries is indicated by thick lines or shades, while admixture is indicated with arrows. My name is Tina and I'm a data scientist at a FAANG company. PubMed Central Lifetime access to all course materials and updates. Biol. 7 Women in Tech You Should Know | Brandwatch Required fields are marked *. Great explanations and feels like real interviews that helps me warm up myself before the real interview! These models are easy to implement as well as really helpful in deciding what to build and how much to invest in it. The resulting GoyetQ2 cluster includes individuals spanning from western France to Poland in the period between 18 and 15ka. Lead Advisor - Data Science. How to Rock at Data Science with Tina Huang Jon Krohn Pleistocene North African genomes link Near Eastern and sub-Saharan African human populations. In the video above, she explains the two major components of big data: data warehousing and data science. We visualize the total amount of ROH longer than 4 cM for (a) pre-LGM individuals, (b) Epigravettian- and Magdalenian-associated individuals, (c) individuals carrying high proportions of Sidelkino-related ancestry, and (d) individuals carrying high proportions of Oberkassel-related ancestry. This Villabruna ancestry(hereafter, Villabruna cluster or ancestry) showed connections to ancient and present-day Near Eastern populations4,16, but the mode and tempo of its expansion into the Italian peninsula remain unexplored. 276, 107319 (2022). wrote the manuscript with input from T.T., E.A., W.H., J. Krause and all other co-authors. The Villabruna ancestry later appeared in central Europe and it is thought to have largely replaced groups related to the GoyetQ2ancestry4. Ancient genomes indicate population replacement in Early Neolithic Britain. 1 and 2). Nature 514, 445449 (2014). and JavaScript. Shes also the creator of the Microsoft Excel spreadsheet Data Mining 101. She has also published a book titled Data Science: Principles and Practices which she wrote with co-author Dan Ariely. Yang, M. A. et al. The sequence alignment/map format and SAMtools. is also supported by the Deutsche Forschungsgemeinschaft (DFG FOR 2237). Both of these ancestries carry a genetic component distantly related to the Goyet Q116-1 individual dated to 35ka, with the Iberian individual also showing an affinity to the Villabruna cluster4,14. Well be back on Friday so, if youre not already, get subscribed to the Brandwatch Bulletin right away. Lifetime access to all course materials and updates. As she gains working experience with one of the FAANG companies, Tina continues to share interesting details about her career journey with the audience. In her journey of eventually becoming a data scientist, Tina started out with an undergraduate in Pharmacology. A dynastic elite in monumental Neolithic society. Article This provides further support for the model with no long-term decline of genome-wide Neanderthal ancestry in modern humans following their introgression18. Citing . Sign up below if you'd like to join a growing community that is enthusiastic about learning and improving their lives. Tina_Huang_Resume_i.pdf - Tina Huang hellotinah@gmail.com The average calibrated date is shown, with pie charts indicating the estimated proportion of ancestry for each group or individual. Villalba-Mouco, V. et al. In other words, youll never have to worry about validity issues or having to re-take the course after a certain amount of time. performed mortuary practices analyses. | pros vs cons. Ancient Rome: A genetic crossroads of Europe and the Mediterranean. and J.Krause performed or supervised genetic analyses. Tina Huang Popularity . Roebroeks, W., Mussi, M., Svoboda, J. How to Rock at Data Science with Tina Huang, Older: Daily Habit #8: Math or Computer Science Exercise . Furthermore, the gene pool of the western Gravettian populations is found continuously for at least 20,000 years: their descendants who are associated with the Solutrean and Magdalenian cultures stayed in southwestern Europe during the coldest period of the last Ice Age (between 25,000 and 19,000 years ago) and later spread north-eastward to the rest of Europe. Nat. Tina Huang is a well-known data scientist who has over 10 years of experience on YouTube and has previously worked at a FAANG organization. Article We were also told that her project was one of the first student projects that has been accepted into a top-tier universitys student programming competition. These European regions, therefore, constitute climatic refugia where human populations survived during the LGM. Conversely,additional Oberkassel ancestry is identified in eastern Europe by at least 7.5ka in newly generated genomes from Minino I and Yazykovo from the upper Volga region, whereasa 1,000-years-older individual from Minino I did not have this genetic component. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. a, Geographic locations of newly reported individuals (filled symbols with black outline) and representative previously published individuals (outlined stars). Protoc. Meyer, M. et al. PLoS Genet. This suggests a very small recent effective population size, estimated to be in the order of around 70 individuals (Supplementary Table 2), causing the low genetic diversity in Sicilian Epigravettian hunter-gatherers. B. et al. The mapped reads from the same individual and library set-up were merged and duplications were removed with DeDup. Reducing microbial and human contamination in DNA extractions from ancient bones and teeth. By contrast, the Goyet Q116-1 genetic profile gave rise to the newly described Fournol cluster identified in Gravettian-associated individuals from western and southwestern Europe. Wonderful course so far Tina. Laplace, G. Essai de Typologie Systmatique (Annali dellUniversit di Ferrara, 1964). CAS 5). 771234-PALEoRIDER (to W.H. Google Scholar. As inferred from the archaeological record35, the spread of the Magdalenian across Europe is linked to southwestern to northern and northeastern post-LGM population expansions and not to movements from southeastern refugia34. This is also validated by f4-statistics of the form f4(Mbuti, Zlat k; test1, test2), which are consistent with zero for all other pre-LGM hunter-gatherers (Supplementary Data 2.C), indicating an equidistant relationship of Zlat k to the tested groups. In product development, we do lots of opportunity sizing to decide which features to build and what opportunities to invest in. Vallini, L. et al. Philos. 359, 318 (2015). The genetic affinity to the Villabruna ancestry is present in El Mirn and in Magdalenian-associated individuals from western and central Europe. Cosimo Posth, He Yu or Johannes Krause. 5 and Supplementary Information, section9). Here, data really gets to shine, in that its both the source of truth and the driver of insights. For contaminated libraries we used the PMD-filtered bam files as the input for genotyping. Tina Huang - Data Scientist - Children's Hospital Los Angeles (CHLA Ecol. Taipei, Taiwan . Martiniano, R., De Sanctis, B., Hallast, P. & Durbin, R. Placing ancient DNA sequences into reference phylogenies. This plot reveals the presence of three distinct groupings: (1) a pre-40ka group with individuals from the UstIshim, Bacho Kiro, Zlat k and Petera cu Oase sites, (2) a Vstonice cluster including Gravettian-associated individuals from centraleastern and southern European sites (Doln Vstonice, Pavlov, Krems-Wachtberg, Paglicci and Ostuni), and (3) a Fournol cluster(hereafter, Fournol cluster or ancestry) comprising Gravettian-associated individuals from western and southwestern European sites (Ormesson, La Rochette, Fournol and two Seriny cave sites (Mollet III and Reclau Viver)). Tina Huang - Climate & Environment Knowledge Analyst - LinkedIn Genome Biol. Curr. Adv. The Solutrean culture is temporally intermediate between the Gravettian and the Magdalenian (or the Badegoulian) cultures, and is found in southwestern and western Europe, which are considered to have been climatic refugia for human populations during the LGM25,26. The aligned sequences of all individuals with new genomic data reported in this study are available at the European Nucleotide Archive (ENA) under study accession number PRJEB51862. After 7.5ka, as ANF ancestry had reached regions north of the Alps, individuals carrying a hunter-gatherer genetic profile were primarily restricted to the northern fringes of Europe (Fig. Data Science Resume Round-Up With @Tina Huang | Episode 3 - KennethJee Paleogenomic evidence for multi-generational mixing between Neolithic farmers and Mesolithic hunter-gatherers in the Lower Danube Basin. Extended Data Fig. Hunter-gatherers carrying an admixed WHG/EHG genetic profile have been sequenced from various regions of northern and eastern Europe, raising the question of how these two types of ancestries formed and interacted with each other through time and space37,38,39,40. USA 111, 22292234 (2014). Surprisingly, the research team found that populations from different regions associated with the Gravettian culture, which was widespread across the European continent between 32,000 and 24,000 years ago, were not closely related to each other. Madrid, Madrid, Spain. Here is a sampling of five herbs that have demonstrated potential immune support benefits: 1. When expanded it provides a list of search options that will switch the search inputs to match the current selection. When Gravettian-associated individuals are included in an admixture graph also featuring Kostenki 14, we find that Fournol 85 fits best as a sister lineage of Goyet Q116-1, whereas the Vstonice group is modelled as a mixture between a lineage related to the Sunghir group and one related to the Goyet Q116-1Fournol 85 branch (Fig. 4 and Supplementary Data 3.C). Saag, L. et al. The error bar shows the s.e.m. The Complete Power BI Practical Course 2020, The 7 Biggest Technology Trends Everyone Must Get Ready For in 2020. I am Tina Huang, PhD, a data scientist, and the director of the Data Science Learning Center at the University of Arizona. These data suggest that the genetic ancestries identified in the pre-40ka individuals analysed so far went largely extinct or were assimilated by subsequent expansions1,9. 864358 (to K.M. The de-multiplexed capture sequencing reads were cleaned and mapped to human reference genome hs37d5 using EAGER pipeline 1.92.5564. a, MDS plot of pre-LGM individuals. 3.Tina Huang. She is also a popular YouTuber with over 60k subscribers. Contact Us. In this video @Tina Huang and I go through 5 subscriber submitted resumes and review them. Klaric, L., Goutas, N., Laccarire, J. I think its cool to see a project like this happen and I hope its interesting for people to learn more about how this stuff works. This article reviews qualitative and quantitative studies related to the academic achievement of youth from immigrant Chinese families. Additional details are provided in SupplementaryInformation, section11 and SupplementaryTable 3. Hi, my name is Tina and I'm a data scientist at a FAANG company. Xinhe Huang - Teaching Assistant - Cardiff University / Prifysgol To bind DNA, silica columns for high volumes (High Pure Viral Nucleic Acid Large Volume Kit (Roche)) were used. Quat. About the author: Tina Huang is a data scientist at one of the FAANG companies. 412, 3743 (2016). Proc. Genomic structure in Europeans dating back at least 36,200 years. Join a growing community of 11K+ to find accountability partners, take part in productivity sprints, and join discord only events! No need to do it alone our community of learners and instructors is there for you. This finding, in conjunction with the genetic affinity of the Villabruna cluster to ancient and present-day Near Eastern ancestries4,15,16 (Supplementary Information, section8, Supplementary Fig.
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